The most commonly used contrast agent for the dGEMRIC technique is Magnevist (Bayer Heathcare). Even though the contrast agent Magnevist has been approved for clinical use as an MRI contrast agent, the dGEMRIC technique itself is an off-label application.

2011-11-24 · The dGEMRIC index has been validated against histologic and biochemical measurements of glycosaminoglycan content in clinical studies . dGEMRIC has potential as a non-invasive technique for monitoring the glycosaminoglycan content of cartilage after repair by various techniques (Figure 6).

The relative GAG concentration is estimated by measuring the T1 values after penetration of The two main 3D techniques that are considered for T1 quantification in dGEMRIC today are 3D-Look-Locker (3D-LL) [ 11, 20] and 3D-variable flip angle (3D-VFA) [ 22, 23 ]. The 3D Look-Locker technique has been validated against the traditional inversion recovery technique. DELAYED GADOLINIUM‐ENHANCED MRI of cartilage (dGEMRIC) is known to be a reliable technique for evaluating the glycosaminoglycan (GAG) concentration of articular cartilage (1, 2). GAGs have side groups that confer a negative charge to the cartilage matrix. Hence, the dGEMRIC technique holds promise for the development of new diagnostic and therapeutic procedures. However, because of the location of the hip joint deep within the body and due to the fairly thin cartilage layers that require high spatial resolution, the diagnosis of early hip joint cartilage alterations may be problematic.

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High resolution fast T1 mapping technique for dGEMRIC @article{Sur2009HighRF, title={High resolution fast T1 mapping technique for dGEMRIC}, author={S. Sur and T. Mamisch and Timothy Hughes and Y. Kim}, journal={Journal of Magnetic Resonance Imaging}, year={2009}, volume={30} } Third, dGEMRIC is a rather complex MRI technique that can be influenced by the patient’s body mass index, the degree of physical activity, and variations in delay between injection of contrast agent and imaging [52, 53]. Noninvasive techniques are needed for the assessment of the repair tissue. HYPOTHESIS: Magnetic resonance imaging (MRI) with delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) can give valuable information regarding the quality and quantity of the repaired cartilage lesion.

Hence, the dGEMRIC technique holds promise for the development of new diagnostic and therapeutic procedures. However, because of the location of the hip joint deep within the body and due to the fairly thin cartilage layers that require high spatial resolution, the diagnosis of early hip joint cartilage alterations may be problematic.

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Copyright © 2016 Elsevier Inc. All rights reserved. PMID: 27568543 [Indexed for MEDLINE] Sammanfattningsvis ter sig dGEMRIC mycket lovande för att öka kunskapen om artrossjukdomens tidiga skeden samt för utvärdering av olika behandlingsfor-mer.

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To determine whether either of two magnetic resonance imaging approaches - delayed gadolinium enhanced magnetic resonance imaging of cartilage (dGEMRIC), or T2 mapping - can detect short-term changes in knee hyaline cartilage among individuals taking a formulation of collagen hydrolysate. Hence, the dGEMRIC technique holds promise for the development of new diagnostic and therapeutic procedures. However, because of the location of the hip joint deep within the body and due to the fairly thin cartilage layers that require high spatial resolution, the diagnosis of early hip joint cartilage alterations may be problematic. T1 - Current knowledge and importance of dGEMRIC techniques in diagnosis of hip joint diseases. AU - Zilkens, Christoph. AU - Tiderius, Carl Johan.

If the T1-rho is shown to be as useful as the dGEMRIC method it can LIBRIS titelinformation: Contrast-enhanced MRI of human knee cartilage : clinical applications of the novel dGEMRIC technique to study glycosaminoglycan SwePub titelinformation: Contrast-enhanced MRI of human knee cartilage Clinical applications of the novel dGEMRIC technique to study glycosaminoglycan Delayed gadolinium‐enhanced MRI of cartilage (dGEMRIC) in early knee for determination of absorbed dose distributions using MRI technique: basic studies. Delayed gadolinium-enhanced. MRI of cartilage (dGEMRIC) is a previously presented method for identification of early OA using magnetic resonance imaging The delayed gadolinium enhanced MRI of cartilage (dGEMRIC) technique is the only non-invasive means to estimate proteoglycan (PG) content in articular MR/CT workflow to enable clinical implementation of the technique. work was to establish dGEMRIC as a method at 7 T by a field strength. In the course of several studies, both dGEMRIC and T2-mapping were as an additional effect size for the evaluation of surgical cartilage repair techniques. Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) is an imaging technique to estimate joint cartilage glycosaminoglycan content by follow-up study including dGEMRIC”, Osteoarthritis and Cartilage, vol. 24, pp.
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Delayed contrast-enhanced MRI of cartilage (dGEMRIC) is a noninvasive technique to study cartilage glycosaminoglycan (GAG) content in vivo. This study evaluates dGEMRIC in patients with preradiographic degenerative cartilage changes. Delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) is sensitive to the glycosaminoglycan content in cartilage that is lost early in the development of osteoarthritis (OA). Hence, the dGEMRIC technique holds promise for the development of … Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) was first described in 1996 as a nondestructive technique for quantitative measurements of glycosaminoglycan (GAG) concentration in articular cartilage samples [].Its translation to clinical platforms as a means of interrogating the molecular aspects of cartilage was demonstrated in 1997 with illustrative examples of apparent … 2012-10-01 (dGEMRIC) is a non-invasive imaging method that measures a surrogate for glycosaminoglycan (GAG) concentration in articular cartilage [1]. GAG is a macromolecule whose con- Background: Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) is a validated technique for evaluating cartilage health in developmental dysplasia of the hip (DDH), which can be a helpful prognosticator for the response to surgical treatments.

T1 - Current knowledge and importance of dGEMRIC techniques in diagnosis of hip joint diseases. AU - Zilkens, Christoph. AU - Tiderius, Carl Johan.
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dGEMRIC, or delayed gadolinium-enhanced MRI of cartilage is a technique that can be used quantitatively to assess glycosaminoglycan content of cartilage or qualitatively to asses the overall structures of cartilage.